Cytochromes P450-mediated degradation of fuel oxygenates by environmental isolates

Degradation of fuel oxygenates and their main intermediates by Aquincola tertiaricarbonis L108.

Growth of Aquincola tertiaricarbonis L108 on the fuel oxygenates methyl tert-butyl ether (MTBE), ethyl tert-butyl ether (ETBE) and tert-amyl methyl ether (TAME), as well as on their main metabolites tert-butyl alcohol (TBA), tert-amyl alcohol (TAA) and 2-hydroxyisobutyrate (2-HIBA) was systematically investigated to characterize the range and rates of oxygenate degradation by this strain. The e...

Analytical Methods for Fuel Oxygenates

A Concise Background on Fuel Oxygenates Fuel oxygenates are oxygencontaining compounds (e.g., ethers and alcohols) that are added to gasoline either to boost the octane rating, to make the fuel burn cleaner by increasing the oxygen content, or to achieve a combination of both. The most commonly used oxygenates are methyl tertiary-butyl ether (MTBE) and ethanol. Other oxygenates include tertiary...

Metabolism of melatonin by human cytochromes p450.

In humans, the pineal hormone melatonin (MEL) is principally metabolized to 6-hydroxymelatonin (6-HMEL), which is further conjugated with sulfate and excreted in urine. MEL O-demethylation represents a minor reaction. The exact role of individual human cytochromes P450 (P450s) in these pathways has not been established. We used a panel of 11 recombinant human P450 isozymes to investigate for th...

Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice.

Signal transducer and activator of transcription (Stat), a family of transcriptional factors, has been demonstrated to play a critical role in gene regulation in response to inflammatory cytokines, such as interferon and interleukin-6. Inflammatory cytokines and bacterial endotoxin are known to suppress, in most of cases, the constitutive or induced cytochromes P450 (P450) in animals and humans...

Synthesis of Biomass-Derived Gasoline Fuel Oxygenates by Microwave Irradiation